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Vitiligo

Vitiligo or leukoderma is a chronic skin disease that causes loss of pigment, resulting in irregular pale patches of skin. The precise cause of vitiligo is complex and not fully understood. There is some evidence that suggests a combination of autoimmune, genetic and environmental factors causes vitiligo. The incidence of vitiligo worldwide is between one and two percent. According to the Diseases Database, the disorder appears in of areas of macular depigmentation, commonly on extensor aspects of extremities, on the face or neck, and in skin folds. The age of onset is often in young adulthood and the condition tends to progress gradually with lesions enlarging and extending until a quiescent state is reached. Half of the people living with vitiligo develop patches of de-pigmented skin appearing on extremities before their 20s. The patches may grow, shrink or remain constant in size. Patches often occur symmetrically across both sides on the body. Occasionally small areas may re-pigment as they are recolonised by melanocytes. The location of vitiligo affected skin changes over time, with some patches re-pigmenting and de-pigmenting.

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Gallbladder Disease

Gallbladder disease includes gallstones and inflammation or infection of the gallbladder. Gallstones are clusters of solid material that form in the gallbladder. These clusters consist of mostly of cholesterol and can cause abdominal pain, especially after consuming fatty foods. The pain may be sharp or dull.
Overweight people have a higher risk for developing gallbladder disease. Overweight people may produce more cholesterol, a fatty substance found in the body, and heighten the risk for gallstones. Sometimes overweight people may have an enlarged gallbladder, which may not work properly.
Fast weight loss of more than three pounds per week or large weight loss can actually increase the chance of developing gallstones. Modest, slow weight loss of about one half to two pounds a week is less likely to cause gallstones. Achieving a healthy weight may lower the risk for developing gallstones.